Population Genetics & Genomics
Felix Breden is an evolutionary biologist who has fallen under the spell of immunoglobulin genes, that code for the almost infinite variability of the antibody/B-cell and T-cell components of the vertebrate adaptive immune system
Our most recent project, iReceptor, is a data integrative platform for sharing and comparing the vast high-throughput sequencing data bases of B-cell and T-cell repertoires. Go to ireceptor.irmacs.sfu.ca for more information.
Our lab also studies the complicated opsin genes underlying tuning of the vertebrate visual system, using guppies and related species.
Avnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F. IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity. Scientific reports. 2016 Feb 16;6:20842.
Breden F, Prak ET, Peters B, Rubelt F, Schramm CA, Busse CE, Vander Heiden JA, Christley S, Bukhari SA, Thorogood A, Matsen IV FA. Reproducibility and reuse of Adaptive immune receptor repertoire Data. Frontiers in immunology. 2017;8.
Rubelt F, Busse CE, Bukhari SA, Bürckert JP, Mariotti-Ferrandiz E, Cowell LG, Watson CT, Marthandan N, Faison WJ, Hershberg U, Laserson U. Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data. Nature immunology. Nature immunology. 2017 Nov 16;18(12):1274.
Wright AE, Darolti I, Bloch NI, Oostra V, Sandkam B, Buechel SD, Kolm N, Breden F, Vicoso B, Mank JE. Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. Nature communications. 2017 Jan 31;8:14251.